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. 1968 Mar 29;159(3822):1479-80.
doi: 10.1126/science.159.3822.1479.

Genetic control of drug levels in man: phenylbutazone

E S Vesell, J G Page

Genetic control of drug levels in man: phenylbutazone

E S Vesell et al. Science. .

Abstract

Phenylbutazone was administered to seven pairs of identical (monozygotic) twins and to seven pairs of fraternal (dizygotic) twins. Individual half-lives ranged from 1.2 to 7.3 days. Subjects with identical genotypes (monozygotic twins) exhibited very similar phenylbutazone half-lives; significantly greater differences in half-life occurred in dizygotic twins. The previously established large variations among individuals in phenylbutazone metabolism appear to be genetically, rather than environmentally, determined.

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