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. 1968 Mar;8(3):319-25.
doi: 10.1016/S0006-3495(68)86490-2.

Evidence for excision of ultraviolet-induced pyrimidine dimers from the DNA of human cells in vitro

J D Regan, J E Trosko, W L Carrier

Evidence for excision of ultraviolet-induced pyrimidine dimers from the DNA of human cells in vitro

J D Regan et al. Biophys J. 1968 Mar.

Abstract

Within 12-24 hr after human cells were irradiated with ultraviolet light, approximately 50% of the ultraviolet-induced pyrimidine dimers were lost from the DNA. Pyrimidine dimers were found in the TCA-soluble fraction of ultraviolet-irradiated cells at 24 hr. Excess thymidine, caffeine, or hydroxyurea had no effect on the loss of pyrimidine dimers from the DNA of ultraviolet-irradiated cells.

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References

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