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. 1969 Jan 31;163(3866):472-3.
doi: 10.1126/science.163.3866.472.

Secretory activity and oncogenicity of a cell line (MDCK) derived from canine kidney

J Leighton, Z Brada, L W Estes, G Justh

Secretory activity and oncogenicity of a cell line (MDCK) derived from canine kidney

J Leighton et al. Science. .

Abstract

A cell line (MDCK) of dog kidney origin grows on a glass surface as a mosaic of epithelium with many multicellular hemispherical vesicles. The cells lining the blisters actively secrete into the cyst cavities. Suspensions of these cells injected intravenously in the chick embryo produce brain metastases resembling adenocarcinoma.

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