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. 1969 Jan 3;163(3862):75-8.
doi: 10.1126/science.163.3862.75.

Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins

M Wikler, H Köhler, T Shinoda, F W Putnam

Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins

M Wikler et al. Science. .

Abstract

The amino acid sequence of fragments obtained by cyanogen bromide cleavage of the mu-chain of a human gammaM-globulin is homologous to the NH(2)-terminal sequences of the gamma-chain of human and rabbit gammaG-globulins and is related to that of human light chains. This supports the hypothesis that light and heavy chains evolved from a common ancestral gene.

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