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. 1969 Mar 7;163(3871):1079-81.
doi: 10.1126/science.163.3871.1079.

Leukotactic factor produced by sensitized lymphocytes

P A Ward, H G Remold, J R David

Leukotactic factor produced by sensitized lymphocytes

P A Ward et al. Science. .

Abstract

Lymph node lymphocytes obtained from guinea pigs exhibiting delayed hypersensitivity are stimulated in vitro by specific antigen to produce a soluble factor that is chemotactic in vitro for mononuclear macrophages. The material is nondialyzable, relatively heat stable, and elutes from Sephadex G-100 in the fraction containing molecules smaller than immunoglobulins.

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