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Case Reports
. 1977 Jun 13;237(24):2630-1.

Intoxication caused by interaction of chloramphenicol and phenytoin

J Q Rose, H K Choi, J J Schentag, W R Kinkel, W J Jusko
  • PMID: 576989
Case Reports

Intoxication caused by interaction of chloramphenicol and phenytoin

J Q Rose et al. JAMA. .

Abstract

A patient with a brain tumor and seizures who was receiving maintenance doses of phenytoin was given chloramphenicol on three occasions. Her neurological status was both complicated and obscured by the reoccurrence of phenytoin intoxication. Retrospective drug analysis showed a marked elevation of serum concentrations of phenytoin during each course of chloramphenicol.

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