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. 1969 Apr;16(4):537-41.

The incidence of spontaneously occurring anti-liver antibodies in New Zealand black mice

C J Elson, J D Naysmith

The incidence of spontaneously occurring anti-liver antibodies in New Zealand black mice

C J Elson et al. Immunology. 1969 Apr.

Abstract

The sera of NZB/BL mice have been found to be active in the complement fixation test against isogeneic liver antigens to a higher titre than the sera of CBA, C57BL and DBA/2 mice. Six sera from NZB mice were fractionated by zone ultracentrifugation in sucrose density gradients and the anti-liver activity was found to sediment with the high molecular weight immunoglobulin. No correlation was found between complement-fixing activity against liver antigens and the presence of globulin on red cells (positive direct Coombs test).

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References

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