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. 1977 Jul 11;238(2):139-41.

Theophylline concentrations in asthmatic patients after administration of aminophylline

T R Kordash, R G Van Dellen, J T McCall
  • PMID: 577283

Theophylline concentrations in asthmatic patients after administration of aminophylline

T R Kordash et al. JAMA. .

Abstract

To test the efficacy of using a weight-derived formula to determine aminophylline dosages, 50 patients hospitalized for treatment of severe asthma were given intravenous aminophylline infusions at a rate of 0.9 mg/kg/hr to a maximum dosage of 1,500 mg/24 hr. Serum theophylline determinations done 12 to 96 hours after institution of this therapy showed levels greater than 20 mg/liter in 34% of these patients. Reliance on weight-derived formulas can be dangerous.

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