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. 1976 Feb;9(2):239-46.
doi: 10.1128/AAC.9.2.239.

Effect of bleomycin on deoxyribonucleic acid synthesis in toluene-treated Escherichia coli cells

S L Ross, R E Moses

Effect of bleomycin on deoxyribonucleic acid synthesis in toluene-treated Escherichia coli cells

S L Ross et al. Antimicrob Agents Chemother. 1976 Feb.

Abstract

The antibiotic bleomycin stimulates deoxyribonucleic acid (DNA) synthesis in toluene-treated Escherichia coli cells. The increase in synthesis is linear with bleomycin concentration. Bleomycin-stimulated DNA synthesis is independent of replication and dependent on DNA polymerase I. Replication is spared as the DNA polymerase I-dependent DNA synthesis increases. Bleomycin does not appear to have any effect on purified E. coli DNA polymerases I or II. Our results suggest that bleomycin causes nicking of the bacterial chromosome with subsequent DNA synthesis catalyzed by DNA polymerase I.

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References

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