doi: 10.1128/AAC.9.2.239.
Effect of bleomycin on deoxyribonucleic acid synthesis in toluene-treated Escherichia coli cells
- PMID: 57740
- PMCID: PMC429510
- DOI: 10.1128/AAC.9.2.239
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Effect of bleomycin on deoxyribonucleic acid synthesis in toluene-treated Escherichia coli cells
Antimicrob Agents Chemother.
1976 Feb.
Abstract
The antibiotic bleomycin stimulates deoxyribonucleic acid (DNA) synthesis in toluene-treated Escherichia coli cells. The increase in synthesis is linear with bleomycin concentration. Bleomycin-stimulated DNA synthesis is independent of replication and dependent on DNA polymerase I. Replication is spared as the DNA polymerase I-dependent DNA synthesis increases. Bleomycin does not appear to have any effect on purified E. coli DNA polymerases I or II. Our results suggest that bleomycin causes nicking of the bacterial chromosome with subsequent DNA synthesis catalyzed by DNA polymerase I.
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