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. 1969 Jan;111(1):23-6.
doi: 10.1042/bj1110023.

Preparation, properties and metabolism of 5,6-monoepoxy-3-dehydroretinal

A K Mallia, M R Lakshmanan, K V John, H R Cama

Preparation, properties and metabolism of 5,6-monoepoxy-3-dehydroretinal

A K Mallia et al. Biochem J. 1969 Jan.

Abstract

1. 5,6-Monoepoxy-3-dehydroretinal was synthesized from 3-dehydroretinyl acetate and characterized. 2. When fed to vitamin A-deficient rats, 5,6-monoepoxy-3-dehydroretinal was converted into 5,6-monoepoxy-3-dehydrovitamin A and stored in the liver. 3. It was demonstrated that the rat possesses the necessary enzymes for the reduction and oxidation of 5,6-monoepoxy-3-dehydroretinal to the corresponding alcohol and acid respectively. 4. The biological potency of the epoxy-3-dehydroretinal by the rat-growth assay (determined by USP XIV procedure) was 1.07% of that of vitamin A.

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