[Vascular hyalinosis in diabetic microangiopathy]

Abstract

A histochemical and immunoluminescent investigation of hyalin of arterioles ans small arteries of the kidney, spleen, pancreas and skin were carried out. In 20 patients with diabetes mellitus of a various degree of gravity and duration hyalinosis represented a manifestation of microangiopathy; it was particularly pronounced in the vessels of the spleen and kidney, and in a lesser degree--in the vessels of the pancreas and skin. The intensity of hyalinosis was directly proportional to the duration of the disease; Immunomorphologically, hyaline masses devealed globulins, gamma M-, gamma G-immunoglobulins, complement, albumins, beta-lipoproteins, fibrinogens, which indicates to a hematogenic nature of the vascular hyalin. The presence in hyalin of G an M-immunoglobulins and complement may testify to the participation in its formation of immune mechanisms, together with metabolic ones.