doi: 10.1038/bjc.1976.67.
DNA polymerase activity in plasma from leukaemic guinea-pigs
- PMID: 57790
- PMCID: PMC2025087
- DOI: 10.1038/bjc.1976.67
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DNA polymerase activity in plasma from leukaemic guinea-pigs
Br J Cancer.
1976 Apr.
Free PMC article
Abstract
Measurement of DNA polymerase in leukaemic guinea-pig plasms reveals the presence of low levels of sedimentable and non-sedimentable enzymic activities. Since the sedimentable DNA polymerase is ribonuclease sensitive, uses poly(C).oligo(dG) as template, and bands in a sucrose density gradient at 1-17 g/ml it is thought to be the GPLV-associated reverse transcriptase. The soluble DNA polymerase is stimulated by ribonuclease and is probably of cellular origin.
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