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. 1977 May 29;222(3):187-96.
doi: 10.1007/BF00717597.

Evidence for a specific transport of D-hexoses across the human term placenta in vitro

M Carstensen, H P Leichweiss, G Molsen, H Schröder

Evidence for a specific transport of D-hexoses across the human term placenta in vitro

M Carstensen et al. Arch Gynakol. .

Abstract

Isolated cotylidons of human term placentas are perfused artificially on the fetal and maternal side. The relative transfer rates of radioactive labelled D-glucose, L-glucose, D-mannose and D-mannitol across the placenta are measured and the inhibition of these transports by phloretin is studied: 1. Transfer rates of D-glucose and D-mannose exceed that of L-glucose about 1.5-4 times. 2. Phloretin (10(-3) mol/l) decreases the transports of D-hexoses, whereas the transport of L-GLUCOSE REMAINS UNAFFECTED. 3. If the concentration of D-glucose is increased, the transport of D-mannose is inhibited competitively. 4. L-glucose and D-mannitol equal in transfer rates. These results show, that D-hexoses cross the human placenta by a specific carrier and by simple diffusion.

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