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. 1969 Mar;111(5):757-61.
doi: 10.1042/bj1110757.

The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis

M Akhtar, I A Watkinson, A D Rahimtula, D C Wilton, K A Munday

The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis

M Akhtar et al. Biochem J. 1969 Mar.

Abstract

The biosynthesis of cholesterol from squalene and tritiated water is described. Degradation of the cholesterol indicated that C-15 may be involved in cholesterol biosynthesis. In accordance with this view it is shown that in the conversion of [2RS-(3)H(2)]mevalonic acid into cholesterol one of the hydrogen atoms at C-15 is removed. A mechanism for the removal of the 14alpha-methyl group in steroid biosynthesis that involves the labilization of a C-15 hydrogen atom is outlined. In accordance with the requirement of this scheme it is shown that 4,4'-dimethyl-cholesta-8,14-dien-3beta-ol is converted into cholesterol.

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