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. 1969 Jun 20;164(3886):1420-1.
doi: 10.1126/science.164.3886.1420.

Acetylcholine receptor: covalent attachment of depolarizing groups at the active site

I Silman, A Karlin

Acetylcholine receptor: covalent attachment of depolarizing groups at the active site

I Silman et al. Science. .

Abstract

Following reduction of the acetylcholine receptor in the electroplax with dithiothreitol, the quaternary ammonium compounds bromoacetylcholine bromide and the p-nitrophenyl ester of (p-carboxyphenyl) trimethylammonium iodide react near the active site probably with a sulfhydryl group. The covalently attached quaternary ammonium moieties additionally interact with the active site noncovalently to activate the receptor and cause depolarization of the cell.

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