Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Jul 19;37(3):219-25.
doi: 10.1007/BF00355490.

The effect of mercuric chloride on the excretion of two urinary enzymes in the rat

F Planas-Bohne

The effect of mercuric chloride on the excretion of two urinary enzymes in the rat

F Planas-Bohne. Arch Toxicol. .

Abstract

The effect of intravenous injections of HgCl2 on the renal excretion of alkaline phosphatase (AP) and leucine aminopeptidase (LAP) was investigated in rats. On the first day after Hg enzyme excretion showed a linear rise with the Hg dose from a threshold value of 0.44 mg Hg/kg. On the second day a statistically significant effect was seen already after 0.25 mg HgKG. After doses of 0.75 mg/kg or more a decrease of enzyme activity below control values occurred which persisted for more than 4 days. Treatment with 2,3-dimercaptopropansulfonate (DMPS) brought about a normalization of AP excretion. An effect on LAP excretion was observed only with early treatment. The same holds for the effect of DMPS on Hg-induced lethality. The usefulness of a measurement of LAP excretion for estimating the exposure to inorganic mercury is discussed.

PubMed Disclaimer

References

    1. Nord Hyg Tidskr. 1951;9:240-9 - PubMed
    1. Biochem Soc Trans. 1975;3(2):294-6 - PubMed
    1. Z Versuchstierkd. 1971;13(1):17-21 - PubMed
    1. Z Klin Chem Klin Biochem. 1967 Mar;5(2):59-63 - PubMed
    1. Z Klin Chem Klin Biochem. 1974 Dec;12(12):543-50 - PubMed

LinkOut - more resources