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Clinical Trial
. 1969 Jun;36(2):368-72.
doi: 10.1111/j.1476-5381.1969.tb09511.x.

Preliminary investigations of a new beta-adrenoceptive receptor blocking drug, LB46, in man

R C Hill, P Turner
Clinical Trial

Preliminary investigations of a new beta-adrenoceptive receptor blocking drug, LB46, in man

R C Hill et al. Br J Pharmacol. 1969 Jun.

Abstract

1. Preliminary studies in man of a new beta-adrenoceptive receptor blocking drug, DL-4-(2-hydroxy-3-isopropylaminopropoxy)-indole (LB46), are described.2. LB46, 0.5 mg by oral administration, appeared to be of similar potency to propranolol 20 mg in inhibiting isoprenaline-induced and exercise-induced tachycardia.3. In comparable beta-receptor blocking doses LB46 did not show the negative chronotropic property possessed by propranolol.

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References

    1. Br J Pharmacol Chemother. 1968 Mar;32(3):663-70 - PubMed

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