[A study of two non-complementary H-2 mutations in mice using skin transplantation and serologic analysis]
[Article in
Russian]
- PMID: 57901
Item in Clipboard
[A study of two non-complementary H-2 mutations in mice using skin transplantation and serologic analysis]
[Article in
Russian]
Genetika.
1975.
Abstract
Hz1 and M505 are two mutants affected the Kend of H-2 major histocompatibility system in mouse. Inability of M505 to complement Hz1 is considered as an evidence that the same gene is altered by both mutations. The gained antigens of two mutants can cross-react in vivo, and the lost antigenic determinants are not identical as revealed in skin grafting tests with presensitized recipients. The antiserum ASY-0,15, (d X a) anti-i, could differentiate between normal and mutant cells as well as between both mutants in absorption tests. These results show that some haptenic determinants are changed in the Hz1 and M505 mutations together with changes of histocompatibility determinants.
Similar articles
-
[A study of H-2 mutations in mice. V. Detection of mutations M505, Hzl and M506 in the host vs transplant reaction].Genetika. 1975;11(10):30-2. Genetika. 1975. PMID: 5338 Russian.
-
Cell-mediated lympholysis responses against autologous cells modified with haptenic sulfhydryl reagents. IV. Self-determinants recognized by wild-type anti-H-2Kb and H-2Db-restricted cytotoxic T cells specific for sulfhydryl and amino-reactive haptens are absent in certain H-2 mutant strains.J Immunol. 1982 Oct;129(4):1525-9. J Immunol. 1982. PMID: 6180015
-
Interaction of alpha 1 with alpha 2 region in class I MHC proteins contributes determinants recognized by antibodies and cytotoxic T cells.J Immunol. 1985 Sep;135(3):2160-6. J Immunol. 1985. PMID: 2410513
-
Immunogenetic analysis of H-2 mutations. III. Genetic mapping and involvement in immune reactions of the H-2ka mutation.J Immunol. 1975 Sep;115(3):716-8. J Immunol. 1975. PMID: 125301
-
The use of H-2 mutants as models for the study of T cell activation.Immunol Rev. 1977;35:179-230. Immunol Rev. 1977. PMID: 70397 Review. No abstract available.