Mathematical analysis of concentration-response relationships. Method for the evaluation of the ED50 and the number of binding sites per receptor molecule using the logit transformation
- PMID: 579093
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Mathematical analysis of concentration-response relationships. Method for the evaluation of the ED50 and the number of binding sites per receptor molecule using the logit transformation
Arzneimittelforschung.
1977.
Abstract
The mathematical analysis of concentration-response relationships is performed by means of the mass law and the drug-receptor theory. It is demonstrated that the calculation of the median effective dose (ED50), which is decisive for the pharmacological characterisation of a certain drug, may only be effected by means of the logit transformation. In addition, it is shown that this transformation is most suitable to evaluate in a mathematically simple way the number of drug binding sites of the receptor molecule.
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