Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1969 May;45(523):319-22.
doi: 10.1136/pgmj.45.523.319.

Defibrination syndrome

M Ata

Defibrination syndrome

M Ata. Postgrad Med J. 1969 May.

Abstract

Three cases of defibrination syndrome and bleeding tendency are described. In each case the aetiology was completely different but thrombocytopenia and fibrinogenopenia were present together. This combination is invariably due to diffuse intravascular clotting and it is suggested that these simple investigations should be asked for in cases of unexplained shock, acute renal failure of obscure origin, severe intravascular haemolysis, septic abortions, etc.

Heparin would appear to be of value in these cases of defibrination.

However, if there is no thrombocytopenia, defibrination may be due to excessive fibrinolysis. This should be treated with anti-fibrinolytics only when an underlying clotting defect has been excluded.

PubMed Disclaimer

References

    1. N Engl J Med. 1965 Dec 16;273(25):1370-8 - PubMed
    1. Arch Intern Med. 1966 Jan;117(1):17-24 - PubMed
    1. Acta Pathol Microbiol Scand. 1966;68(4):517-34 - PubMed
    1. Blood. 1967 May;29(5):713-21 - PubMed
    1. Br J Haematol. 1967 Jul;13(4):528-49 - PubMed