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. 1969 Aug 15;165(3894):709-11.
doi: 10.1126/science.165.3894.709.

Serum elastase inhibitor deficiency and alpha 1-antitrypsin deficiency in patients with obstructive emphysema

G M Turino, Seniorrm, B D Garg, S Keller, M M Levi, I Mandl

Serum elastase inhibitor deficiency and alpha 1-antitrypsin deficiency in patients with obstructive emphysema

G M Turino et al. Science. .

Abstract

A decreased inhibition of pancreatic elastase has been detected in the serums of six patients with alpha(1)-antitrypsin deficiency. Five have severe clinical and physiological pulmonary emphysema. This observation extends the defect of inhibition by serum to a second, biologically active proteolytic enzyme in this form of familial emphysema.

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