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. 1969 Jul;48(7):1173-6.
doi: 10.1172/JCI106081.

The discrimination of phenotypes for rate of disappearance of isonicotinoyl hydrazide from serum

E M Scott, R C Wright, D D Weaver

The discrimination of phenotypes for rate of disappearance of isonicotinoyl hydrazide from serum

E M Scott et al. J Clin Invest. 1969 Jul.

Abstract

Expression of the rate of inactivation of isonicotinoyl hydrazide (INH) as a first-order constant gave better discrimination of slow and rapid inactivators than did the level of INH at the end of 6 hr. The most probable division point between the two classes was at k = 0.130. Rate of inactivation by obligatory heterozygotes was determined. Such heterozygotes could not be adequately differentiated from homozygous rapid inactivators. The gene frequency for slow inactivation was 0.46 +/-0.04 in Alaskan Eskimos and 0.62+/-0.06 in Athabaskan Indians.

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