Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1969 Aug 8;165(3893):601-2.
doi: 10.1126/science.165.3893.601.

Oxygen-hemoglobulin dissociation curves: effect of inherited enzyme defects of the red cell

M Delivoria-Papadopoulos, F A Oski, A J Gottlieb

Oxygen-hemoglobulin dissociation curves: effect of inherited enzyme defects of the red cell

M Delivoria-Papadopoulos et al. Science. .

Abstract

The blood of a patient with a deficiency of hexokinase in the red cells and a decreased concentration of 2, 3-diphosphoglycerate in the red cells showed an increased affinity for oxygen, whereas a patient with a deficiency of pyruvate kinase and an elevated concentration of 2, 3-diphosphoglycerate in the red cells had blood with a decreased affinity for oxygen. Defects in red cell glycolysis may alter the oxygen affinity of blood by virtue of their effect on 2, 3-diphosphoglycerate concentrations in red cells.

PubMed Disclaimer

LinkOut - more resources