doi: 10.1083/jcb.42.1.308.
RNA synthesis in Chinese hamster cells. II. Increase in rate of RNA synthesis during G1
- PMID: 5795885
- PMCID: PMC2107561
- DOI: 10.1083/jcb.42.1.308
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RNA synthesis in Chinese hamster cells. II. Increase in rate of RNA synthesis during G1
J Cell Biol.
1969 Jul.
Abstract
Cultures of mitotic Chinese hamster cells, prepared by mechanical selection, were pulse-labeled with methionine-methyl-(14)C or with uridine-(3)H at different stages in the life cycle. The rate of (14)C incorporation into 18S RNA was measured, as was the rate of uridine-(3)H incorporation into total RNA for both monolayer and suspension cultures. The rate of incorporation increased continuously throughout interphase in a fashion inconsistent with a gene-dosage effect upon RNA synthesis.
