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. 1969 Aug 16;3(5667):394-6.
doi: 10.1136/bmj.3.5667.394.

Inhibition by aspirin of release of antiheparin activity from human platelets

A H Youssef, P Barkhan

Inhibition by aspirin of release of antiheparin activity from human platelets

A H Youssef et al. Br Med J. .

Abstract

Both in vitro and in vivo, aspirin inhibited the adenosine diphosphate and collagen-induced release of platelet factor 4 (antiheparin factor). The release induced by adrenaline and thrombin was not affected. The in-vivo effect in normal persons lasted for at least three days. Platelet uptake of acetyl-(14)C-aspirin was significantly greater than that of carboxyl-(14)C-aspirin.

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