[Drug influence on the acute thrombophlebitic edema (author's transl)]

Abstract

The effect of benzopyrones on edema formation in acute thrombophlebitis was investigated in dogs. Thrombophlebitis was produced by the ligation of the femoral vein and the injection of turpentine oil. The benzopyrones delayed edema formation and sped its regression. Protein concentration in lymph and tissue fluid of the edematous extremity was not significantly higher than in the same fluids of the intact limb, and no significant differences were observed in lymphatic and tissue fluid protein concentrations between the treated and untreated animals. It is concluded that the benzopyrones have their main effect on edema in acute thrombophlebitis by causing proteolysis and enhancing the removal of protein from the tissue fluid.