Induction of immunologic tolerance in nursing neonates by absorption of tolerogen from colostrum
- PMID: 58025
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Induction of immunologic tolerance in nursing neonates by absorption of tolerogen from colostrum
J Immunol.
1976 May.
Abstract
Deaggregatedhuman gamma-globulin (DHGG) injected into female mice within 24 hr after delivery of a litter enters the colostrum and is absorbed intact through the intestine by nursing neonates. This absorbed HGG was present in the neonatal circulation at concentrations of 0.3 to 0.6 mg/ml of serum under the experimental conditions used. This absorption of HGG by the nursing neonate resulted in a complete, specific, tolerant state to HGG. This tolerant state was stable upon adoptive cell transfer and could not be abrogated by transfer of normal syngeneic spleen cells.
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