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. 1976 May;116(5):1204-7.

Induction of immunologic tolerance in nursing neonates by absorption of tolerogen from colostrum

J F Halsey, D C Benjamin
  • PMID: 58025

Induction of immunologic tolerance in nursing neonates by absorption of tolerogen from colostrum

J F Halsey et al. J Immunol. 1976 May.

Abstract

Deaggregatedhuman gamma-globulin (DHGG) injected into female mice within 24 hr after delivery of a litter enters the colostrum and is absorbed intact through the intestine by nursing neonates. This absorbed HGG was present in the neonatal circulation at concentrations of 0.3 to 0.6 mg/ml of serum under the experimental conditions used. This absorption of HGG by the nursing neonate resulted in a complete, specific, tolerant state to HGG. This tolerant state was stable upon adoptive cell transfer and could not be abrogated by transfer of normal syngeneic spleen cells.

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