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. 1969 Aug;99(2):459-62.
doi: 10.1128/jb.99.2.459-462.1969.

Correlation between growth inhibition and the binding of various penicillins and cephalosporins to Staphylococcus aureus

J R Edwards, J T Park

Correlation between growth inhibition and the binding of various penicillins and cephalosporins to Staphylococcus aureus

J R Edwards et al. J Bacteriol. 1969 Aug.

Abstract

The concentration of penicillin (or cephalosporin) required to achieve a given rate of binding to Staphylococcus aureus H correlates well with that required for inhibition of growth. This result suggests that the irreversible binding of penicillins and cephalosporins to cells is responsible for their biological activity.

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