Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1969 Mar;35(3):530-42.
doi: 10.1111/j.1476-5381.1969.tb08294.x.

Some hepatotoxic actions of hexachloroethane and its metabolites in sheep

J S Fowler

Some hepatotoxic actions of hexachloroethane and its metabolites in sheep

J S Fowler. Br J Pharmacol. 1969 Mar.

Abstract

1. Pentachloroethane and tetrachloroethylene were major metabolites of hexachloroethane in sheep.2. Concentrations of hexachloroethane, pentachloroethane and tetrachloroethylene were determined by gas-liquid chromatography in blood, bile, faeces, urine and tissues after oral administration of hexachloroethane emulsions to sheep.3. Increased blood concentrations of sorbitol dehydrogenase, glutamate dehydrogenase, and ornithine carbamoyl transferase were found to follow oral administration of hexachloroethane or pentachloroethane.4. The rate of bromsulphthalein transfer from liver cells to bile was found to decrease after oral administration of hexachloroethane.

PubMed Disclaimer

References

    1. Biochem J. 1952 May;51(2):193-201 - PubMed
    1. Res Vet Sci. 1967 Oct;8(4):454-62 - PubMed
    1. Cornell Vet. 1958 Jul;48(3):305-12 - PubMed
    1. J Comp Pathol. 1967 Oct;77(4):405-11 - PubMed
    1. Adv Enzymol Relat Subj Biochem. 1962;24:291-358 - PubMed

MeSH terms

LinkOut - more resources