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. 1978 May;42(5):395-7.
doi: 10.1111/j.1600-0773.1978.tb02223.x.

Terbutaline preventing permeability effects of histamine in the lung

C G Persson, M Ekman, I Erjefält

Terbutaline preventing permeability effects of histamine in the lung

C G Persson et al. Acta Pharmacol Toxicol (Copenh). 1978 May.

Abstract

In unanaesthetized guinea-pigs the effect of terbutaline on histamine-induced increase in lung weight was studied. Terbutaline 0.1 mg/kg and 0.3 mg/kg was given subcutaneously 5 min. before exposure during 60 min. to a histamine aerosol. Terbutaline markedly prevented the histamine-induced increase in lung weight. This effect is discussed in relation to the mechanism of action of mediator-induced increase in vascular permeability.

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