The effect of prostaglandins on the human pregnant uterus
- PMID: 5823677
- DOI: 10.1111/j.1471-0528.1969.tb06178.x
The effect of prostaglandins on the human pregnant uterus
Abstract
PIP: Observations were made in 15 patients in late pregnancy (36-42 weeks) and in 5 in early pregnancy in order to study the effects of intravenous infusion of pure prostaglandins on the mobility of the human pregnant uterus. Uterine contractibility was recorded by means of the Oxford Tocograph. Using both the E prostaglandins and those of the F series, stimulation of myometrial contractility was observed. The oxytocic properties of the E prostaglandins were particularly marked and reliable. In late pregnancy, and at term, the response was characterized by an increase in both the frequency and amplitude of contractions, without -- in the dosage used -- any appreciable increase in tone. Hypertonus was a feature of the response during the early months of pregnancy. Slow in action, the induced level of uterine activity tended to persist or recur for long after the infusion was discontinued and, particularly in the case of prostaglandin E2, was often followed by the successful induction of labor. On the basis of this study, it appears that the effect of prostaglandins in bringing about termination of pregnancy may be indirect.
Similar articles
-
Effect of intravenous infusion of prostaglandin E1 and E2 on motility of the pregnant human uterus. Prostaglandins and related factors 65.Am J Obstet Gynecol. 1968 Oct 1;102(3):317-26. doi: 10.1016/0002-9378(68)90001-x. Am J Obstet Gynecol. 1968. PMID: 5675882
-
The effect of the prostaglandin F compounds on the contractility of the pregnant human uterus.Am J Obstet Gynecol. 1970 Feb 15;106(4):567-72. doi: 10.1016/0002-9378(70)90042-6. Am J Obstet Gynecol. 1970. PMID: 5412850
-
Effects of oral administration of prostaglandins E 2 and F 2- on the human uterus.J Obstet Gynaecol Br Commonw. 1971 Apr;78(4):289-93. doi: 10.1111/j.1471-0528.1971.tb00274.x. J Obstet Gynaecol Br Commonw. 1971. PMID: 5558311 Clinical Trial. No abstract available.
-
[Potential obstetrical application of prostaglandins].Nihon Sanka Fujinka Gakkai Zasshi. 1985 Dec;37(12):2857-61. Nihon Sanka Fujinka Gakkai Zasshi. 1985. PMID: 3910743 Review. Japanese.
-
Hormonal effects on human myometrial activity.Vitam Horm. 1973;31:257-303. doi: 10.1016/s0083-6729(08)61000-6. Vitam Horm. 1973. PMID: 4620376 Review.
Cited by
-
Prostaglandins in human reproduction.Br Med J (Clin Res Ed). 1981 Dec 12;283(6306):1563-6. doi: 10.1136/bmj.283.6306.1563. Br Med J (Clin Res Ed). 1981. PMID: 6796167 Free PMC article. Review. No abstract available.
-
Induction of abortion by extra-amniotic administration of prostaglandins E2 and F2-alpha.Br Med J. 1972 Jul 15;3(5819):146-9. doi: 10.1136/bmj.3.5819.146. Br Med J. 1972. PMID: 5039777 Free PMC article.
-
Prostaglandins. Has the initial promise been realised?Drugs. 1983 Jan;25(1):1-5. doi: 10.2165/00003495-198325010-00001. Drugs. 1983. PMID: 6825614
-
Therapeutic abortion by intrauterine instillation of prostaglandins.Br Med J. 1971 Mar 13;1(5749):588-90. doi: 10.1136/bmj.1.5749.588. Br Med J. 1971. PMID: 5548301 Free PMC article.
-
Use of prostaglandin E2 for therapeutic abortion.Br Med J. 1970 Jul 25;3(5716):198-200. doi: 10.1136/bmj.3.5716.198. Br Med J. 1970. PMID: 5311029 Free PMC article.