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. 1965 Sep 3;149(3688):1093-5.
doi: 10.1126/science.149.3688.1093.

Turnover of ribosomal RNA in rat liver

J N Loeb, R R Howell, G M Tomkins

Turnover of ribosomal RNA in rat liver

J N Loeb et al. Science. .

Abstract

After a single injection of radioactive orotic acid and a "chase" of nonradioactive precursor, the specific activity of ribosomal RNA in rat liver decreases logarithmically at a rate corresponding to a half-life of about S days. The possible significance of this result is discussed with regard to control of protein synthesis.

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