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. 1965 Sep 3;149(3688):1111-3.
doi: 10.1126/science.149.3688.1111.

DNA: reaction with chloroquine

J L Allison, R L O'Brien, F E Hahn

DNA: reaction with chloroquine

J L Allison et al. Science. .

Abstract

Diflerence spectrophotometry shows that double-stranded DNA produces mnarked changes in the absorption spectrum of chloroquine; only minor changes occur with single-stranded DNA. A DNA-chloroquine complex was demonstrated to sediment in the analytical ultracentrifuge. Chloroquine strongly elevated the thermal dissociation temperature, T(m), of DNA. It is concluded that the drug forms a complex with DNA by ionic interaction and stabilizes the helix.

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