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. 1965 Aug 27;149(3687):998-1000.
doi: 10.1126/science.149.3687.998.

Focal antibody production by transferred spleen cells in irradiated mice

J H Playfair, B W Papermaster, L J Cole

Focal antibody production by transferred spleen cells in irradiated mice

J H Playfair et al. Science. .

Abstract

Lethally irradiated mice were injected with small numbers of normal spleen cells and then immunized with sheep erythrocytes. Antibody activity was found in their spleens in localized areas whose number corresponded to the number of spleen cells injected. When sheep and pig erythrocytes were injected together, antibody against each was found in separate areas. Each area may consist of the progeny of a single precursor cell, restricted to forming a single antibody.

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