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. 1965 Sep;9(3):281-6.

The activity of different fractions of homologous thyroid extract in the production of allergic thyroiditis in the rat

I M Roitt, H E Jones, G L Mills

The activity of different fractions of homologous thyroid extract in the production of allergic thyroiditis in the rat

I M Roitt et al. Immunology. 1965 Sep.

Abstract

Rat thyroglobulin with a high degree of ultracentrifugal purity can be obtained by zone ultracentrifugation of crude thyroid extracts. The thyroglobulin fraction was even more effective than the original extract as an antigen for the production of experimental allergic thyroiditis. Material in the extracts with lower sedimentation coefficients than thyroglobulin were ineffective as antigens in this respect as was a homologous thyroid microsomal fraction.

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References

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