Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1965 Jul;26(1):19-24.
doi: 10.1083/jcb.26.1.19.

The cell generation cycle of the eleven-day mouse embryo

M Atlas, V P Bond

The cell generation cycle of the eleven-day mouse embryo

M Atlas et al. J Cell Biol. 1965 Jul.

Abstract

The incorporation of tritiated thymidine into the DNA of erythroblasts, primitive ependymal cells, and mesenchymal cells of 11-day mouse embryos was studied by radioautography at different times between 25 minutes and 18 hours after injection intraperitoneally. There was no labeling of mitotic figures until 1 hour after injection. Following this, mitotic figures were labeled for about 5.5 hours in primitive ependymal cells and mesenchymal cells, and for a longer period in erythroblasts. The percentage of the labeled primitive ependymal cells at various times after injection indicate a periodic migration into and out of the mitotic zone. The cell generation cycle of primitive ependymal cells and mesenchymal cells is similar to some kinds of adult cells. The cycle of the erythroblasts is more like that of the cells of aging mice.

PubMed Disclaimer

References

    1. J Cell Physiol. 1950 Dec;36(3):381-409 - PubMed
    1. Proc Soc Exp Biol Med. 1959 Jul;101(3):557-60 - PubMed
    1. Exp Cell Res. 1961 Aug;24:334-43 - PubMed
    1. J Histochem Cytochem. 1960 May;8:171-81 - PubMed
    1. Ann N Y Acad Sci. 1959 Jun 25;77:803-20 - PubMed