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. 1965 Sep;96(3):879-85.
doi: 10.1042/bj0960879.

A fluorimetric study of the hydroxylation of biphenyl in vitro by liver preparations of various species

P J Creaven, D V Parke, R T Williams

A fluorimetric study of the hydroxylation of biphenyl in vitro by liver preparations of various species

P J Creaven et al. Biochem J. 1965 Sep.

Abstract

1. A study has been made of the enzymic hydroxylation of biphenyl by liver microsomal preparations from 11 species of animals, by using a fluorescence method for the micro-estimation of the hydroxylation products, 2- and 4-hydroxybiphenyl. 2. Livers from all species examined produced 4-hydroxybiphenyl, but only those from mice, hamsters, cats, coypus and frogs produced 2-hydroxybiphenyl as well. 3. Adult rat and rabbit livers produced only the 4-isomer, but livers from the young of these species also produced the 2-isomer. 4. The properties and requirements of the 4-hydroxylating enzyme of rabbit liver were studied. 5. The results are discussed and it is suggested that the 2- and 4-hydroxylating enzymes are different.

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References

    1. Biochem J. 1965 Aug;96(2):390-8 - PubMed
    1. Biochem J. 1965 Sep;96(3):872-8 - PubMed
    1. Arch Biochem Biophys. 1956 Apr;61(2):431-41 - PubMed

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