Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1965 Sep;49(1):17-25.
doi: 10.1085/jgp.49.1.17.

Maximum rate of depolarization of single muscle fiber in normal and low sodium solutions

A Ferroni, D Blanchi

Maximum rate of depolarization of single muscle fiber in normal and low sodium solutions

A Ferroni et al. J Gen Physiol. 1965 Sep.

Abstract

The values of membrane action potentials and maximum depolarization rates of single muscle fibers in normal Tyrode solution and in low sodium solutions containing as little as 20 per cent of the sodium chloride were measured with intracellular microelectrodes. Under these conditions the membrane potential remains unchanged up to 36 per cent of [Na(+)](out) concentration, whereas the overshoot of the action potential varies linearly with the logarithm of the external sodium concentration. The maximum depolarization rate is a linear function of the external sodium concentration. The results obtained support the ionic theory for sodium and the independence principle for sodium current related to the external sodium concentration.

PubMed Disclaimer

References

    1. J Physiol. 1952 Apr;116(4):449-72 - PubMed
    1. J Physiol. 1960 Dec;154(2):385-407 - PubMed
    1. J Physiol. 1951 Feb;112(3-4):476-95 - PubMed
    1. J Physiol. 1952 Aug;117(4):500-44 - PubMed
    1. Pflugers Arch. 1953;257(1):20-34 - PubMed