Inhibition of Newcastle disease virus replication by 6-azauridine. II. Combination of 6-azauridine and adenine derivatives
- PMID: 5863
Item in Clipboard
Inhibition of Newcastle disease virus replication by 6-azauridine. II. Combination of 6-azauridine and adenine derivatives
Acta Virol.
1976 Apr.
Abstract
Twenty-five metabolites (purines, pyrimidines, nucleosides and nucleosides) were tested for their simultaneous action with 6-azauridine (AzUrd) in inhibition of Newcastle disease virus (NDV) replication. With the exception of deoxyadenosine and cyclic AMP all natural adenine derivatives exerted a synergic effect with AzUrd like ATP. Glutamine in combination with AzUrd did not inhibit NDV replication. The inhibitory effect of the combination of AzUrd and adenine derivatives was reversible by guanosine, uridine and cytidine but not by orotic acid or orotidylic acid.
Similar articles
-
Inhibition of Newcastle disease virus replication by 6-azauridine. I. Inefficacy of purified uridine kinase, effect of adenosine-5'-triphosphate.Acta Virol. 1976 Apr;20(2):97-101. Acta Virol. 1976. PMID: 5878
-
Antiviral action and selectivity of 6-azauridine.Ann N Y Acad Sci. 1977 Mar 4;284:410-7. doi: 10.1111/j.1749-6632.1977.tb21977.x. Ann N Y Acad Sci. 1977. PMID: 280143
-
Synergistic effect of purine derivatives on the toxicity of pyrazofurin and 6-azauridine towards cultured mammalian cells.J Cell Physiol. 1982 Jun;111(3):291-4. doi: 10.1002/jcp.1041110310. J Cell Physiol. 1982. PMID: 6178748
-
[Disorders of human pyrimidine metabolism (author's transl)].MMW Munch Med Wochenschr. 1975 Sep;117(37):1453-6. MMW Munch Med Wochenschr. 1975. PMID: 810667 Review. German.
-
Analogs of pyrimidine and purine mononucleotide precursors as metabolic inhibitors.Pharmacol Ther. 1981;13(3):385-420. doi: 10.1016/0163-7258(81)90022-x. Pharmacol Ther. 1981. PMID: 7025038 Review. No abstract available.