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. 1977 Oct 1;167(1):281-4.
doi: 10.1042/bj1670281.

Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C

M G Low, J B Finean

Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C

M G Low et al. Biochem J. .

Abstract

Purified phosphatidylinositol-specific phospholipase C from Staphylococcus aureus released a substantial proportion of the total alkaline phosphatase activity from a wide range of tissues from several mammalian species. Co-purification of the phospholipase C and alkaline phosphatase-releasing activities and the inhibition of both these activities by iso-osmotic salt solutions suggested that the releasing effect was unlikely to be due to a contaminant.

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