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. 1965 Sep 17;149(3690):1390-1.
doi: 10.1126/science.149.3690.1390.

Prostaglandin: release from the rat phrenic nerve--diaphragm preparation

P W Ramwell, J E Shaw, J Kucharski

Prostaglandin: release from the rat phrenic nerve--diaphragm preparation

P W Ramwell et al. Science. .

Abstract

Release of a substance that stimulates smooth muscle was detected from a phrenic nerve-diaphragm preparation from the rat upon direct and indirect stimulation. On thin-layer chromatography most of the active material behaved as a mixture of prostaglandins. The effect of electrical stimulation was mimicked by catecholamines but not by acetylcholine or eserine. The effect of nerve stimulation was not antagonized by d-tubocurarine.

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