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. 1965 Jun;8(6):590-603.

Multiple nature of the third component of guinea-pig complement. I. Separation and characterization of three factors a, b, and c, essential for haemolysis

P G Klein, H J Wellensiek

Multiple nature of the third component of guinea-pig complement. I. Separation and characterization of three factors a, b, and c, essential for haemolysis

P G Klein et al. Immunology. 1965 Jun.

Abstract

Three factors essential for the lysis of EAC′142 cells are described and designated as a, b and c. These factors exhibit characteristic properties with respect to certain inactivating agents. They can be neatly separated by chemical fractionation. A simple assay method is described for each factor. Preparative methods for two highly reactive intermediate cellular products are given. Evidence is presented suggesting that besides a, b and c at least two additional factors are involved in the lytic action of C′3.

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