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. 1977 Nov 26;2(6099):1414.
doi: 10.1136/bmj.2.6099.1414.

Post-pill amenorrhoea

Post-pill amenorrhoea

R P Shearman. Br Med J. .

Abstract

PIP: The writer has always used a 12-month period before diagnosing secondary amenorrhea whereas a previously published article used a 4-month period. The spontaneous cure rate of amenorrhea of this short duration is relatively high. The writer has never claimed a causal relationship between oral contraceptives and secondary amenorrhea, but there is a high index of suspicion. Full investigation should be made, mainly to exclude pituitary tumor. In a recent series of patients with galactorrhea and amenorrhea, 20 of 25 with proved pituitary adenomas gave a history of oral contraceptive use. Clomiphene-responsive amenorrhea patients represent a heterogeneous group of disparate causes of anovulation and should not be grouped together. After 12 months or more of amenorrhea, patients followed-up for 18 months to 11 years still had a 30% persistence of the condition.

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References

    1. Lancet. 1977 Jun 4;1(8023):1195-7 - PubMed
    1. Lancet. 1968 Feb 17;1(7538):325-6 - PubMed
    1. Contraception. 1975 Feb;11(2):123-32 - PubMed

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