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Comparative Study
. 1977 Nov-Dec;4(6):593-6.
doi: 10.1111/j.1440-1681.1977.tb02691.x.

A comparative study of antipyrine pharmacokinetics in saliva and plasma using a colourimetric method of antipyrine analysis

A E Harman, B G Priestly, D B Frewin
Comparative Study

A comparative study of antipyrine pharmacokinetics in saliva and plasma using a colourimetric method of antipyrine analysis

A E Harman et al. Clin Exp Pharmacol Physiol. 1977 Nov-Dec.

Abstract

1. Half-life, apparent volume of distribution and metabolic clearance rate for antipyrine elimination were reliably estimated from either plasma or saliva samples. 2. Pharmacokinetic analysis of antipyrine from saliva utilizing a simple and sensitive colourimetric technique provided a convenient method for assessing the activity of hepatic microsomal drug-metabolizing enzymes.

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