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. 1977 Dec 15;46(4):377-81.
doi: 10.1016/0014-2999(77)90232-1.

3H-Spiroperidol labels dopamine receptors in pituitary and brain

I Creese, R Schneider, S H Snyder

3H-Spiroperidol labels dopamine receptors in pituitary and brain

I Creese et al. Eur J Pharmacol. .

Abstract

3H-Spiroperidol of high specific radioactivity labels dopamine receptors in membranes of bovine caudate nucleus and anterior pituitary. The saturation and kinetic properties of 3H-spiroperidol binding are similar in the two tissues. In both caudate and pituitary 3H-spiroperidol displays very high affinity with a dissociation constant of 0.2-0.3 nM. The relative potencies of numerous dopamine agonists and antagonists in competing for 3H-spiroperidol binding are closely similar in anterior pituitary and caudate.

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