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. 1966 Mar;98(3):869-73.
doi: 10.1042/bj0980869.

Dealkylation studies on inhibited acetylcholinesterase

D B Coult, D J Marsh, G Read

Dealkylation studies on inhibited acetylcholinesterase

D B Coult et al. Biochem J. 1966 Mar.

Abstract

1. A rapid method for measuring the rate of dealkylation of organophosporus-inhibited enzymes is described. 2. The dealkylation rates have been measured for acetylcholinesterase inhibited by isopropyl, sec.-butyl, 1,2-dimethylpropyl, 1,2,2-trimethylpropyl and cyclohexyl methylphosphonofluoridate, and by di-isopropyl phosphorofluoridate; they are first-order under the conditions used.

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