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. 1966 Sep 16;153(3742):1403-5.
doi: 10.1126/science.153.3742.1403.

Coding properties of 7-methylguanine

R C Wilhelm, D B Ludlum

Coding properties of 7-methylguanine

R C Wilhelm et al. Science. .

Abstract

The abnormal base, 7-methylguanine, has been introduced into copolymers of uridylic and guanylic acids by methylation under controlled conditions. The resulting methylated copolymers have a markedly decreased template activity for polypeptide synthesis in vitro due to steric effects of the 7-methyl groups. Contrary to expectation, these polymers do not permit incorporation of amino acids whose codons contain the bases uracil and adenine.

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