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. 1966 Sep 23;153(3743):1539-43.
doi: 10.1126/science.153.3743.1539.

Hemoglobins in sheep: multiple differences in amino acid sequences of three beta-chains and possible origins

S H Boyer, P Hathaway, F Pascasio, C Orton, J Bordley, M A Naughton

Hemoglobins in sheep: multiple differences in amino acid sequences of three beta-chains and possible origins

S H Boyer et al. Science. .

Abstract

Among the three adult sheep hemoglobins (A, B, and C), two (A and B) are reportedly products of alleles. The beta-chains of A and B differ by at least seven scattered amino acid residues whereas the beta-sequence of C differs from A by at least 16 residues and from B by at least 21 residues. These changes suggest that the origin of C-beta antedated the divergence of A and B. Five shared differences between A-beta and C-beta with respect to B-beta can be interpreted as the result of selective advantage in favor of B. A complex of additional mechanisms has possibly been involved in maintaining the A-B- C porymorphism.

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