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. 1966 Sep 2;153(3740):1125-7.
doi: 10.1126/science.153.3740.1125.

Nucleic acid guanine: reaction with the carcinogen N-acetoxy-2-acetylaminofluorene

E C Miller, U Juhl, J A Miller

Nucleic acid guanine: reaction with the carcinogen N-acetoxy-2-acetylaminofluorene

E C Miller et al. Science. .

Abstract

Reaction of N-acetoxy-2-acetylaminofluorene with DNA or RNA at pH 7 causes marked increase in absorption at 280 to 320 millimicrons and marked decrease in guanine content. Reaction with guanosine-8-(14)C yields a radioactive fluorescent derivative. The data suggest that metabolic esters of N-hydroxy-2-acetylaminofluorene may be intermediates in the binding of this proximate carcinogen to nucleic acids in vivo.

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